Progranulin polymorphism rs5848 is associated with increased risk of Alzheimer's disease.

doi:10.1016/j.gene.2014.03.041

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Progranulin polymorphism rs5848 is associated with increased risk of Alzheimer's disease.

Gene - 1 Jun 2014

Sheng Jinghao, Su Liling, Xu Zhengping, Chen Guangdi

Abstract excerpt

Progranulin is the precursor of granulins, and its down-regulation leads to neurodegeneration. Recent studies have indicated an association of progranulin polymorphism rs5848 with Alzheimer's disease (AD) risk, but the results remain controversial. To verify the association between rs5848 and AD risk, we retrieved the published literature from PubMed and other databases, and performed a meta-analysis by pooling...

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Identifiers

PMID: 24680777
DOI: 10.1016/j.gene.2014.03.041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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