Article
Two new and distinct roles for Drosophila Argonaute-2 in the nucleus: alternative pre-mRNA splicing and transcriptional repression.
Genes & development - 15 Feb 2013
Taliaferro J Matthew, Aspden Julie L, Bradley Todd, Marwha Dhruv, Blanchette Marco, Rio Donald C
Abstract excerpt
Transcription and pre-mRNA alternative splicing are highly regulated processes that play major roles in modulating eukaryotic gene expression. It is increasingly apparent that other pathways of RNA metabolism, including small RNA biogenesis, can regulate these processes. However, a direct link between alternative pre-mRNA splicing and small RNA pathways has remained elusive. Here we show that the small RNA...
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