Alternative transcription initiation leads to expression of a novel ALK isoform in cancer.

doi:10.1038/nature15258

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Article

Alternative transcription initiation leads to expression of a novel ALK isoform in cancer.

Nature - 15 Oct 2015

Wiesner Thomas, Lee William, Obenauf Anna C, Ran Leili, Murali Rajmohan, Zhang Qi Fan, Wong Elissa W P, Hu Wenhuo, Scott Sasinya N, Shah Ronak H, Landa Iñigo, Button Julia, Lailler Nathalie, Sboner Andrea, Gao Dong, Murphy Devan A, Cao Zhen, Shukla Shipra, Hollmann Travis J, Wang Lu, Borsu Laetitia, Merghoub Taha, Schwartz Gary K, Postow Michael A, Ariyan Charlotte E, Fagin James A, Zheng Deyou, Ladanyi Marc, Busam Klaus J, Berger Michael F, Chen Yu, Chi Ping

Abstract excerpt

Activation of oncogenes by mechanisms other than genetic aberrations such as mutations, translocations, or amplifications is largely undefined. Here we report a novel isoform of the anaplastic lymphoma kinase (ALK) that is expressed in ∼11% of melanomas and sporadically in other human cancer types, but not in normal tissues. The novel ALK transcript initiates from a de novo alternative transcription initiation...

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PMID: 26444240
DOI: 10.1038/nature15258
PMCID: PMC4807020

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