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Article

Targeting oncogenic ALK: a promising strategy for cancer treatment.

Molecular cancer therapeutics - 1 Apr 2011

Grande Enrique, Bolós María-Victoria, Arriola Edurne

Abstract excerpt

Recently, the anaplastic lymphoma kinase (ALK) has been found to be altered in several solid and hematologic tumors. Novel drugs targeting this tyrosine kinase receptor are under development, and early clinical trials are showing promising activity in non-small cell lung cancer patients with ALK+ tumors. Here, we review the structure and function of the ALK receptor, the mechanisms associated with its...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21474455
DOI: 10.1158/1535-7163.MCT-10-0615

Genes

ALK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology.Semantic proximity Read ↗

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