Article
Genomic and experimental evidence that alternate transcription initiation of the Anaplastic Lymphoma Kinase (ALK) kinase domain does not predict single agent sensitivity to ALK inhibitors
2019-07-09
Abstract excerpt
Genomic data can facilitate personalized treatment decisions by enabling therapeutic hypotheses in individual patients. Conditional selection, which includes mutual exclusivity, is a signal that has been empirically useful for identifying mutations that may be sensitive to single agent targeted therapies. However, a low mutation frequency can underpower this signal for rare variants and prevent robust conclusions...
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Identifiers and source
- Literature Corpus work
- 3a4aa836-e9fa-5e0e-adf0-6950d4a029ce
- DOI
- 10.1101/696294