Article
Core domain mutant Y220C of p53 protein has a key role in copper homeostasis in case of free fatty acids overload.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine - 1 Dec 2015
Arciello Mario, Longo Alessia, Viscomi Carmela, Capo Concetta, Angeloni Antonio, Rossi Luisa, Balsano Clara
Abstract excerpt
Nonalcoholic fatty liver disease (NAFLD) is a pathology that includes a wide variety of clinical conditions ranging from simple steatosis to end-stage liver diseases. Despite the huge amount of researches, the molecular basis of NAFLD are still not fully understood. Recently, it was suggested a role for p53 in NAFLD pathogenesis. Among its targets there is Synthesis of Cytochrome c Oxidase 2 (SCO2), a copper...
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