Article

GRP78/BiP alleviates oxLDL-induced hepatotoxicity in familial hypercholesterolemia caused by missense variants of LDLR

2023-02-24

Abstract excerpt

<title>Abstract</title> <p><bold>Background and Aims- </bold>Endoplasmic Reticulum (ER) stress, caused by aberrantly trafficked proteins that are encoded by genetic variants of functional genes, is a critical consequence in human disorders such as familial hypercholesterolemia, cardiovascular and hepatic diseases. In addition to the identification of ER stress as a contributing factor to pathogenicity, extensive...

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Literature Corpus work: b34797aa-e0e4-57da-9765-b5108403fb85
DOI: 10.21203/rs.3.rs-2615406/v1

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