Article

Copper-induced suppression of the PPARα–FABP1 axis sensitizes hepatocytes to ferroptosis in Wilson disease

2026-02-25

Abstract excerpt

<title>Abstract</title> <p> Wilson disease (WD) is characterized by hepatic copper accumulation and progressive liver injury, yet the mechanisms linking copper overload to hepatocellular damage remain incompletely understood. Here, we identify suppression of the PPARα–FABP1 axis as a key metabolic vulnerability that sensitizes hepatocytes to ferroptosis in WD. Liver tissues from WD patients and <italic>Atp7b</i...

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Literature Corpus work: 24b53d23-e647-5f9a-8474-a89f6dfc742b
DOI: 10.21203/rs.3.rs-8847209/v1

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