Article

The development of an optimized and reliable iron overload HepG2 cell model

2022-08-24

Abstract excerpt

Cell-based iron overload models provide tremendous utility for the investigations into the pathogenesis of different diseases as well as assessing efficacy of various therapeutic strategies. In the literature, establishing such models vary tremendously with regards to cell lines, iron source, iron treatment conditions and duration. Due to this diversity, researchers reported significant differences in the measured...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f2f3bc87-45fd-578a-801f-4ed55c2d1b70
DOI: 10.21203/rs.3.rs-1976449/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The development of an optimized and reliable iron overload HepG2 cell modelDOI 10.21203/rs.3.rs-1976449/v1Read

Iron overload triggers redox-sensitive signals in human IMR-32 neuroblastoma cellsSemantic proximity Read

Iron-Induced Liver Injury: A Critical ReappraisalSemantic proximity Read

Commonly used organoid culture media prevent ferroptosisSemantic proximity Read

Non-cytotoxic copper overload boosts mitochondrial energy metabolism to modulate cell proliferation and differentiation in the human erythroleukemic cell line K562Semantic proximity Read

Iron chelation as a new therapeutic approach to prevent senescence and liver fibrosis progressionSemantic proximity Read

[Iron homeostasis, a defense mechanism in oxidative stress].Semantic proximity Read

The Evolution of Iron Chelators for the Treatment of Iron Overload Disease and CancerSemantic proximity Read

Iron Metabolism in Cancer and Senescence: A Cellular PerspectiveSemantic proximity Read

A Computational Model of Liver Iron MetabolismSemantic proximity Read

3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and FerroptosisSemantic proximity Read

Iron accumulation during cellular senescence.Semantic proximity Read

Molecular and cellular insights into iron regulationSemantic proximity Read