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Article

Reduced variation around drug-resistant dhfr alleles in African Plasmodium falciparum.

Molecular biology and evolution - 1 Sept 2005

Pearce Richard, Malisa Allen, Kachur S Patrick, Barnes Karen, Sharp Brian, Roper Cally

Abstract excerpt

We have measured microsatellite diversity at 26 markers around the dhfr gene in pyrimethamine-sensitive and -resistant parasites collected in southeast Africa. Through direct comparison with diversity on sensitive chromosomes we have found significant loss of diversity across a region of 70 kb around the most highly resistant allele which is evidence of a selective sweep attributable to selection through...

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PMID: 15917494
DOI: 10.1093/molbev/msi177

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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