Article
Regional variation in sulfadoxine-pyrimethamine resistance genotypes and haplotypes of Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase genes in Western Kenya.
Malaria journal - 1 Oct 2025
Bungei Josephat, Ouma Collins, Zhong Daibin, Oyweri Job, Lee Ming-Chieh, Zhou Guofa, Atieli Harrysone, Githure John, Wang Chloe, Yan Guiyun
Abstract excerpt
BACKGROUND: Surveillance of molecular markers associated with antimalarial resistance in Plasmodium falciparum is critical for tracking the emergence, evolution, and spread of resistant malaria parasites in the population for timely and effective interventions. As shifting use of sulfadoxine-pyrimethamine (SP) in Kenya constitutes a differential selection pressure, this study compared resistance genotypes and...
Topics
- Tetrahydrofolate Dehydrogenase
- Kenya
- Plasmodium falciparum
- Pyrimethamine
- Sulfadoxine
- Haplotypes
- Dihydropteroate Synthase
- Drug Combinations
- Drug Resistance
- Antimalarials
- Cross-Sectional Studies
- Genotype