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Article

A novel diagnostic biosensor for distinguishing immunoglobulin mutated and unmutated types of chronic lymphocytic leukemia.

Biosensors & bioelectronics - 15 Mar 2016

Ensafi Ali A, Amini Maryam, Rezaei Behzad, Talebi Majid

Abstract excerpt

In chronic lymphocytic leukemia (CLL), the immunoglobulin heavy-chain variable (IgVH) region may be mutated (Ig-mutated CLL) or unmutated (Ig-unmutated CLL); and the presence or absence of mutations in this region of CLL cells distinguishes two clinically distinct forms. It is important for physicians to distinguish between patients with Ig-unmutated CLL, where typically have more indolent disease with median...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Immunoglobulin G

Share to Leukemia, Lymphocytic, Chronic, B-Cell

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Share to Sensitivity and Specificity

Share to ZAP-70 Protein-Tyrosine Kinase

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Identifiers

PMID: 26436328
DOI: 10.1016/j.bios.2015.09.063

Genes

ZAP70

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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