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Nanozyme-Enhanced Paper-Based Bipolar Electrode Biosensor for Dual-Mode Detection for M918T in Serum with Single-Base Specificity.

Analytical chemistry - 2 Jun 2026

Miao Chen-Fang, Zhang Yu, Lin Zhen, Huang Guo-Hao, Liu Ai-Lin, Lei Yun

Abstract excerpt

The RET M918T mutation is a critical biomarker for early screening of medullary thyroid carcinoma (MTC). However, its ultralow abundance amid excess wild-type sequences poses challenges for accurate detection and limits the suitability of conventional methods for rapid point-of-care testing (POCT). Herein, a paper-based bipolar electrode-electrochemiluminescence (BPE-ECL) and colorimetry dual-modal biosensor...

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PMID: 42133984
DOI: 10.1021/acs.analchem.5c07317

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RET

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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