Article
Electrochemical biosensors for analysis of DNA point mutations in cancer research.
Analytical and bioanalytical chemistry - 1 Mar 2023
Ondraskova Katerina, Sebuyoya Ravery, Moranova Ludmila, Holcakova Jitka, Vonka Petr, Hrstka Roman, Bartosik Martin
Abstract excerpt
Cancer is a genetic disease induced by mutations in DNA, in particular point mutations in important driver genes that lead to protein malfunctioning and ultimately to tumorigenesis. Screening for the most common DNA point mutations, especially in such genes as TP53, BRCA1 and BRCA2, EGFR, KRAS, or BRAF, is crucial to determine predisposition risk for cancer or to predict response to therapy. In this review, we...
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