Article
Genotyping of common EGFR mutations in lung cancer patients by electrochemical biosensor.
Journal of pharmaceutical and biomedical analysis - 20 Feb 2018
Weng Xiu-Hua, Xu Xiong-Wei, Wang Chang-Lian, Lin Wei-Wei, Liu Ai-Lin, Chen Wei, Lin Xin-Hua
Abstract excerpt
In this study, we constructed a sandwich-type biosensor to identify six common types of mutations in exon 19 of the epidermal growth factor receptor (EGFR) gene, and tested them using tissue samples from patients with non-small cell lung carcinomas. Considering the characteristics that different locations of non-complementary in DNA probes resulting in different hybridization efficiency, we investigated the...
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