Article

Human cytomegalovirus infection coopts chromatin organization to diminish TEAD1 transcription factor activity

2024-04-13

Abstract excerpt

<h4>Summary</h4> Human cytomegalovirus (HCMV) infects up to 80% of the world’s population. Here, we show that HCMV infection leads to widespread changes in human chromatin accessibility and chromatin looping, with hundreds of thousands of genomic regions affected 48 hours after infection. Integrative analyses reveal HCMV-induced perturbation of Hippo signaling through drastic reduction of TEAD1 transcription fact...

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Literature Corpus work: 8691cc0f-dc91-563a-a53a-ca06fea378a2
DOI: 10.1101/2024.04.12.588762

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