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Article

H3K27-specific demethylase orchestrates the phenotypic and functional plasticity of intestinal ILC3s.

Cell reports - 27 Jan 2026

Gao Xianzhi, Shen Xin, Xu Qianying, Dong Linjia, Zeng Yan, Hong Shenghui, Jin Huihui, Wang Qianqian, Wang Di, Lu Linrong, Yu Jingjing, Wang Lie

Abstract excerpt

Group 3 innate lymphoid cells (ILC3s) exhibit dynamic plasticity, with their differentiation and function orchestrated by epigenetic mechanisms, including histone modifications and DNA methylation. We identify the histone demethylases UTX and JMJD3 as pivotal regulators of ILC3 specialization. Their deficiency disrupts subset balance: NKp46+ ILC3s are depleted with impaired IL-22 production, whereas CCR6+ ILC3s...

Topics

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Epigenesis, Genetic
Histone Demethylases
Histones
Immunity, Innate
Interleukin-22

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Jumonji Domain-Containing Histone Demethylases

Source

Identifiers

PMID: 41557504
DOI: 10.1016/j.celrep.2025.116862

Genes

CCR6
TCF7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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