Article
Interferon Lambda 4 Genotype Is Not Associated with Recurrence of Oral or Genital Herpes.
PloS one - 1 Jan 2015
Lang Kuhs Krystle A, Kuniholm Mark H, Pfeiffer Ruth M, Chen Sabrina, Desai Seema, Edlin Brian R, Peters Marion G, Plankey Michael, Sharp Gerald B, Strickler Howard D, Villacres Maria C, Quinn Thomas C, Gange Stephen J, Prokunina-Olsson Ludmila, Greenblatt Ruth M, O'Brien Thomas R
Abstract excerpt
IFNL4-ΔG/TT (rs368234815) genotype is associated with hepatitis C virus clearance and may play a role in other infections. IFN-λ4 protein is generated only in individuals who carry the IFNL4-ΔG allele. The IFNL4 rs12979860-T allele, which is in strong linkage disequilibrium with IFNL4-ΔG, was recently reported to be associated with more frequent and severe oral herpes episodes. We investigated the association of...
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