Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotype.

PLoS genetics - 1 Aug 2011

Shapiro Irina M, Cheng Albert W, Flytzanis Nicholas C, Balsamo Michele, Condeelis John S, Oktay Maja H, Burge Christopher B, Gertler Frank B

Abstract excerpt

Epithelial-mesenchymal transition (EMT), a mechanism important for embryonic development, plays a critical role during malignant transformation. While much is known about transcriptional regulation of EMT, alternative splicing of several genes has also been correlated with EMT progression, but the extent of splicing changes and their contributions to the morphological conversion accompanying EMT have not been...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alternative Splicing
Share to Breast Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Movement

Share to Epithelial-Mesenchymal Transition

Share to Mesenchymal Stem Cells

Share to Repressor Proteins

Share to RNA-Binding Proteins

Share to RNA Splicing Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 21876675
DOI: 10.1371/journal.pgen.1002218
PMCID: PMC3158048

Genes

RBFOX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotype.PMID 21876675Read ↗

Identification of a core EMT signature that separates basal-like breast cancers into partial- and post-EMT subtypesSemantic proximity Read ↗

Splicing factor ratio as an index of epithelial-mesenchymal transition and tumor aggressiveness in breast cancerSemantic proximity Read ↗

Epithelial-Mesenchymal Transition—A Hallmark of Breast Cancer MetastasisSemantic proximity Read ↗

CD44 splice isoform switching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progressionSemantic proximity Read ↗

A cell-to-patient machine learning transfer approach uncovers novel basal-like breast cancer prognostic markers amongst alternative splice variantsSemantic proximity Read ↗

A cell-to-patient machine learning transfer approach uncovers novel basal-like breast cancer prognostic markers amongst alternative splice variantsSemantic proximity Read ↗

Exon-level transcriptome profiling in murine breast cancer reveals splicing changes specific to tumors with different metastatic abilities.Semantic proximity Read ↗

Comparing transcriptional dynamics of the epithelial-mesenchymal transitionSemantic proximity Read ↗

The role of alternative splicing in cancer.Semantic proximity Read ↗

Epithelial-mesenchymal transition markers screened in a cell-based model and validated in lung adenocarcinomaSemantic proximity Read ↗

An In Vitro Model That Recapitulates the Epithelial to Mesenchymal Transition (EMT) in Human Breast CancerSemantic proximity Read ↗

Integrative Transcriptomic Analysis Reveals a Multiphasic Epithelial–Mesenchymal Spectrum in Cancer and Non-tumorigenic CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.