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Article

The Study of SRSF1 Regulates Abnormal Alternative Splicing of BCL2L11 and the Role in Refractory Acute Myeloid Leukemia.

Chemotherapy - 1 Jan 2024

Wang Qirong, Duan Yu, Zan Zhifang, Yang Kai, Wang Jinjuan, Jia Fengfeng, Tan Yanhong, Wang Hongwei, Li Li

Abstract excerpt

INTRODUCTION: Abnormalities in splicing factors, such as mutations or deregulated expression, can lead to aberrant splicing of target genes, potentially contributing to the pathogenesis of acute myeloid leukemia (AML). Despite this, the precise mechanism underlying the abnormal alternative splicing (AS) induced by SRSF1, a splicing factor associated with poor AML prognosis, remains elusive. METHODS: Using strict...

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PMID: 38763139
DOI: 10.1159/000539414

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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