Article
JEPEGMIX: gene-level joint analysis of functional SNPs in cosmopolitan cohorts.
Bioinformatics (Oxford, England) - 15 Jan 2016
Lee Donghyung, Williamson Vernell S, Bigdeli T Bernard, Riley Brien P, Webb Bradley T, Fanous Ayman H, Kendler Kenneth S, Vladimirov Vladimir I, Bacanu Silviu-Alin
Abstract excerpt
MOTIVATION: To increase detection power, gene level analysis methods are used to aggregate weak signals. To greatly increase computational efficiency, most methods use as input summary statistics from genome-wide association studies (GWAS). Subsequently, gene statistics are constructed using linkage disequilibrium (LD) patterns from a relevant reference panel. However, all methods, including our own Joint Effect...
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