Article
Meta-analysis of gene-level tests for rare variant association.
Nature genetics - 1 Feb 2014
Liu Dajiang J, Peloso Gina M, Zhan Xiaowei, Holmen Oddgeir L, Zawistowski Matthew, Feng Shuang, Nikpay Majid, Auer Paul L, Goel Anuj, Zhang He, Peters Ulrike, Farrall Martin, Orho-Melander Marju, Kooperberg Charles, McPherson Ruth, Watkins Hugh, Willer Cristen J, Hveem Kristian, Melander Olle, Kathiresan Sekar, Abecasis Gonçalo R
Abstract excerpt
The majority of reported complex disease associations for common genetic variants have been identified through meta-analysis, a powerful approach that enables the use of large sample sizes while protecting against common artifacts due to population structure and repeated small-sample analyses sharing individual-level data. As the focus of genetic association studies shifts to rare variants, genes and other...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.