Article
DISTMIX: direct imputation of summary statistics for unmeasured SNPs from mixed ethnicity cohorts.
Bioinformatics (Oxford, England) - 1 Oct 2015
Lee Donghyung, Bigdeli T Bernard, Williamson Vernell S, Vladimirov Vladimir I, Riley Brien P, Fanous Ayman H, Bacanu Silviu-Alin
Abstract excerpt
MOTIVATION: To increase the signal resolution for large-scale meta-analyses of genome-wide association studies, genotypes at unmeasured single nucleotide polymorphisms (SNPs) are commonly imputed using large multi-ethnic reference panels. However, the ever increasing size and ethnic diversity of both reference panels and cohorts makes genotype imputation computationally challenging for moderately sized computer...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.