Article

Computationally efficient meta-analysis of gene-based tests using summary statistics in large-scale genetic studies

2024-12-08

Abstract excerpt

Meta-analysis of gene-based tests using single variant summary statistics is a powerful strategy for associating genes with disease. However, current approaches require sharing the covariance matrix between variants for each study and trait of interest. For large-scale studies with many phenotypes, these matrices can be cumbersome to calculate, store, and share. To address this challenge, we present REMETA, an eff...

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Literature Corpus work: 78f9ba5b-93ec-5f81-ba4b-53b7d23d86a2
DOI: 10.1101/2024.12.06.24318617

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