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Article

Fitness Studies of Azole-Resistant Strains of Aspergillus fumigatus.

Antimicrobial agents and chemotherapy - 1 Dec 2015

Valsecchi Isabel, Mellado Emilia, Beau Rémi, Raj Shriya, Latgé Jean-Paul

Abstract excerpt

Isogenic bar-coded strains of Aspergillus fumigatus carrying the G54W or M220K mutation in Cyp51A were constructed. In vitro, the growth and conidiation capacities of the mutants were similar to those of the parental strain. Competition studies in the absence of azoles showed that there was no adverse fitness cost for the azole-resistant A. fumigatus strains in vitro or in vivo compared to the parental strain.

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Share to Antifungal Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Cytochrome P-450 Enzyme System

Share to Drug Resistance, Fungal

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Source

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Identifiers

PMID: 26416854
DOI: 10.1128/AAC.01594-15
PMCID: PMC4649223

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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