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Article

cyp51A gene silencing using RNA interference in azole-resistant Aspergillus fumigatus.

Mycoses - 1 Dec 2015

Mousavi Bita, Hedayati Mohammad T, Teimoori-Toolabi Ladan, Guillot Jacques, Alizadeh Ahad, Badali Hamid

Abstract excerpt

An increasing number of reports have described the emergence of acquired resistance of Aspergillus fumigatus to azole compounds. The primary mechanism of resistance in clinical isolates is the mutation of the azole drug target enzyme, which is encoded by the cyp51A gene. The aim of this study was to evaluate the impact of silencing the cyp51A gene in azole-resistant A. fumigatus isolates. A 21-nucleotide...

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Share to Antifungal Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26448519
DOI: 10.1111/myc.12417

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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