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Article

First Clinical Isolation of an Azole-Resistant Aspergillus fumigatus Isolate Harboring a TR46 Y121F T289A Mutation in South America.

Antimicrobial agents and chemotherapy - 1 Oct 2018

Isla Guillermina, Leonardelli Florencia, Tiraboschi Iris N, Refojo Nicolás, Hevia Alejandra, Vivot Walter, Szusz Wanda, Córdoba Susana B, García-Effron Guillermo

Abstract excerpt

One of the most recently described Aspergillus fumigatusCYP51A-mediated azole resistance mechanisms is TR46 Y121F T289A. Clinical A. fumigatus strains harboring these substitutions have been reported worldwide, with the exception of South America. We describe the first clinical A. fumigatus strain with this resistance mechanism isolated from an Argentinian patient. The strain was isolated in 2009 (1 year after...

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Identifiers

PMID: 30082288
DOI: 10.1128/AAC.00872-18
PMCID: PMC6153829

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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