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Article

Characteristics of individual cyp51A SNPs and combinations thereof impacting the azole phenotype in TR34-mediated resistance genotypes of Aspergillus fumigatus.

Antimicrobial agents and chemotherapy - 4 Mar 2026

Song Yinggai, Buil Jochem B, Zoll Jan, Tehupeiory-Kooreman Marlou, Venselaar Hanka, Li Ruoyu, Melchers Willem J G, Verweij Paul E

Abstract excerpt

The World Health Organization has flagged the rise of drug resistance in Aspergillus fumigatus as a critical concern. Elevated mutation rates in this pathogen contribute to the rapid development of resistance, complicating treatment efforts. We conducted a study on the prevalence of azole resistance among clinical A. fumigatus isolates in the Netherlands from 1994 to 2022 and identified 34 cyp51A variants. To...

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Antifungal Agents
Aspergillosis
Aspergillus fumigatus
Azoles
Cytochrome P-450 Enzyme System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Drug Resistance, Fungal

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PMID: 41631961
DOI: 10.1128/aac.01528-25
PMCID: PMC12959090

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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