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Article

Mechanistic Basis for Epitope Proofreading in the Peptide-Loading Complex.

Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2015

Fleischmann Gerda, Fisette Olivier, Thomas Christoph, Wieneke Ralph, Tumulka Franz, Schneeweiss Clemens, Springer Sebastian, Schäfer Lars V, Tampé Robert

Abstract excerpt

The peptide-loading complex plays a pivotal role in Ag processing and is thus central to the efficient immune recognition of virally and malignantly transformed cells. The underlying mechanism by which MHC class I (MHC I) molecules sample immunodominant peptide epitopes, however, remains poorly understood. In this article, we delineate the interaction between tapasin (Tsn) and MHC I molecules. We followed the...

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Source

Identifiers

PMID: 26416272
DOI: 10.4049/jimmunol.1501515

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mechanistic Basis for Epitope Proofreading in the Peptide-Loading Complex.PMID 26416272Read ↗

CryoEM structure of an MHC-I/TAPBPR peptide bound intermediate reveals the mechanism of antigen proofreadingSemantic proximity Read ↗

Reanalysis of Immunopeptidomics Datasets Provides Mechanistic Insight into TAPBPR-Mediated Peptide Editing on HLA-A, -B and -C MoleculesSemantic proximity Read ↗

Exchange catalysis by tapasin exploits conserved and allele-specific features of MHC-I molecules.Semantic proximity Read ↗

Reanalysis of Immunopeptidomics Datasets Provides Mechanistic Insight into TAPBPR-Mediated Peptide Editing on HLA-A, -B and -C MoleculesSemantic proximity Read ↗

A loop structure allows TAPBPR to exert its dual function as MHC I chaperone and peptide editorSemantic proximity Read ↗

Redox regulation facilitates optimal peptide selection by MHC class I during antigen processing.Semantic proximity Read ↗

Structure and Dynamics of Antigenic Peptides in Complex with TAPSemantic proximity Read ↗

TAPBPR mediates peptide dissociation from MHC class I using a leucine lever.Semantic proximity Read ↗

TAPBPR promotes antigen loading on MHC-I molecules using a peptide trap.Semantic proximity Read ↗

MHC class II complexes sample intermediate states along the peptide exchange pathwaySemantic proximity Read ↗

Identifying MHC class I epitopes by predicting the TAP transport efficiency of epitope precursors.Semantic proximity Read ↗

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