Article
Redox regulation facilitates optimal peptide selection by MHC class I during antigen processing.
Cell - 20 Oct 2006
Park Boyoun, Lee Sungwook, Kim Eunkyung, Cho Kwangmin, Riddell Stanley R, Cho Sunglim, Ahn Kwangseog
Abstract excerpt
Activated CD8(+) T cells discriminate infected and tumor cells from normal self by recognizing MHC class I-bound peptides on the surface of antigen-presenting cells. The mechanism by which MHC class I molecules select optimal peptides against a background of prevailing suboptimal peptides and in...
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