Article
Cervical Cytology Preserves Histologically Detected Surface Epithelial Slackening, Unique to the POLE Mutation-subtype in Endometrial Cancer.
In vivo (Athens, Greece) - 1 Jan 2000
Kitazono Ikumi, Akahane Toshiaki, Yokoyama Seiya, Kubota Emi, Nishida-Kirita Yukari, Noguchi Hirotsugu, Murakami Miki, Yanazume Shintaro, Kobayashi Hiroaki, Tanimoto Akihide
Abstract excerpt
BACKGROUND/AIM: Among the four genomic subtypes of endometrial cancer, distinguishing between the DNA polymerase epsilon mutation (POLEmut) and no specific molecular profile (NSMP) subtypes requires genomic profiling owing to the lack of surrogate immunohistochemical markers. We have previously found that, histologically, the POLEmut-subtype exhibits surface epithelial slackening (SES). Therefore, to improve...
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