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Article

Early divergence of Th1 and Th2 transcriptomes involves a small core response and sets of transiently expressed genes.

European journal of immunology - 1 Apr 2013

van den Ham Henk-Jan, de Waal Leon, Zaaraoui-Boutahar Fatiha, Bijl Maarten, van Ijcken Wilfred F J, Osterhaus Albert D M E, de Boer Rob J, Andeweg Arno C

Abstract excerpt

Th cells can adopt a number of different phenotypes. We performed microarray-assisted mRNA profiling on antigen-stimulated, TCR transgenic murine splenocytes that were cultured in the presence of cytokines. Transcriptome snapshots of Th cells differentiating into Th1 and Th2 phenotypes were obtained at various time points. Principal component analysis shows that time since activation and Th skewing are the...

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PMID: 23436590
DOI: 10.1002/eji.201242979

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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