Article

Differentiation is accompanied by a progressive loss in transcriptional memory

2022-11-03

Abstract excerpt

Cell differentiation requires the integration of two opposite processes, a stabilizing cellular memory, especially at the transcriptional scale, and a burst of gene expression variability which follows the differentiation induction. Therefore, the actual capacity of a cell to undergo phenotypic change during a differentiation process relies upon a modification in this balance which favors change-inducing gene expr...

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Literature Corpus work: 609168dc-74d4-566b-9a19-b626cdbda2ae
DOI: 10.1101/2022.11.02.514828

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