Article
Next generation sequencing in synovial sarcoma reveals novel gene mutations.
Oncotarget - 27 Oct 2015
Vlenterie Myrella, Hillebrandt-Roeffen Melissa H S, Flucke Uta E, Groenen Patricia J T A, Tops Bastiaan B J, Kamping Eveline J, Pfundt Rolph, de Bruijn Diederik R H, Geurts van Kessel Ad H M, van Krieken Han J H J M, van der Graaf Winette T A, Versleijen-Jonkers Yvonne M H
Abstract excerpt
Over 95% of all synovial sarcomas (SS) share a unique translocation, t(X;18), however, they show heterogeneous clinical behavior. We analyzed multiple SS to reveal additional genetic alterations besides the translocation. Twenty-six SS from 22 patients were sequenced for 409 cancer-related genes using the Comprehensive Cancer Panel (Life Technologies, USA) on an Ion Torrent platform. The detected variants were...
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