Article
Molecular profiling of soft tissue sarcomas using next-generation sequencing: a pilot study toward precision therapeutics.
Human pathology - 1 Aug 2014
Jour George, Scarborough John D, Jones Robin L, Loggers Elizabeth, Pollack Seth M, Pritchard Colin C, Hoch Benjamin L
Abstract excerpt
Next-generation sequencing (NGS) can provide in-depth detection of numerous gene alterations. To date, there are very few reports describing the use of this technique in soft tissue sarcomas. Herein, we aim to test the utility of NGS in identifying targetable mutations in these tumors. NGS was performed using a clinically validated multiplexed gene sequencing panel interrogating the full coding sequence of 194...
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