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Article

Synovial Sarcoma With BRAF V600E Mutation: A Case Report and Literature Review.

Genes, chromosomes & cancer - 1 May 2026

Gao Tian, Deng Tao, Shi Yunfei, Yang Fan, Xiao Sheng, Fan Zhengfu

Abstract excerpt

Synovial sarcoma (SS) is a genetically defined soft tissue sarcoma driven by the pathognomonic SS18::SSX fusion and is generally characterized by a low burden of secondary genomic alterations. We report a 42-year-old man with metastatic SS harboring both the SS18::SSX1 rearrangement and the BRAF V600E mutation. The patient developed metastatic disease following standard multimodal therapy. Comprehensive genomic...

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Identifiers

PMID: 42084470
DOI: 10.1002/gcc.70128

Genes

BRAF
SS18
SSX1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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