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Article

Next-Generation Sequencing in Translational Sarcoma Research: Biological Insights and Emerging Directions.

Current oncology reports - 17 Sept 2026

De Vita Alessandro, Violani Sara, Miserocchi Giacomo, Xerxa Elena, Bajorath Jürgen, Vanni Silvia

Abstract excerpt

PURPOSE OF REVIEW: Sarcomas are rare and heterogeneous malignancies for which molecular diagnostics increasingly complement histopathology, immunohistochemistry, FISH, and RT-PCR. This review summarizes the main research applications of next-generation sequencing (NGS) in sarcoma, with particular attention to mutation and variant discovery, fusion detection, biomarker development, assay validation, multi-omics...

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Topics

Humans
Sarcoma
High-Throughput Nucleotide Sequencing
Translational Research, Biomedical
Biomarkers, Tumor
Mutation

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Source

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Identifiers

PMID: 42753035
DOI: 10.1007/s11912-026-01828-w
PMCID: PMC13585967

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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