Article
Clinical genomic profiling in the management of patients with soft tissue and bone sarcoma.
Nature communications - 15 Jun 2022
Gounder Mrinal M, Agaram Narasimhan P, Trabucco Sally E, Robinson Victoria, Ferraro Richard A, Millis Sherri Z, Krishnan Anita, Lee Jessica, Attia Steven, Abida Wassim, Drilon Alexander, Chi Ping, Angelo Sandra P D', Dickson Mark A, Keohan Mary Lou, Kelly Ciara M, Agulnik Mark, Chawla Sant P, Choy Edwin, Chugh Rashmi, Meyer Christian F, Myer Parvathi A, Moore Jessica L, Okimoto Ross A, Pollock Raphael E, Ravi Vinod, Singh Arun S, Somaiah Neeta, Wagner Andrew J, Healey John H, Frampton Garrett M, Venstrom Jeffrey M, Ross Jeffrey S, Ladanyi Marc, Singer Samuel, Brennan Murray F, Schwartz Gary K, Lazar Alexander J, Thomas David M, Maki Robert G, Tap William D, Ali Siraj M, Jin Dexter X
Abstract excerpt
There are more than 70 distinct sarcomas, and this diversity complicates the development of precision-based therapeutics for these cancers. Prospective comprehensive genomic profiling could overcome this challenge by providing insight into sarcomas' molecular drivers. Through targeted panel sequencing of 7494 sarcomas representing 44 histologies, we identify highly recurrent and type-specific alterations that aid...
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