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Article

V-1 regulates capping protein activity in vivo.

Proceedings of the National Academy of Sciences of the United States of America - 25 Oct 2016

Jung Goeh, Alexander Christopher J, Wu Xufeng S, Piszczek Grzegorz, Chen Bi-Chang, Betzig Eric, Hammer John A

Abstract excerpt

Capping Protein (CP) plays a central role in the creation of the Arp2/3-generated branched actin networks comprising lamellipodia and pseudopodia by virtue of its ability to cap the actin filament barbed end, which promotes Arp2/3-dependent filament nucleation and optimal branching. The highly conserved protein V-1/Myotrophin binds CP tightly in vitro to render it incapable of binding the barbed end. Here we...

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Identifiers

PMID: 27791032
DOI: 10.1073/pnas.1605350113
PMCID: PMC5087048

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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