Article
Putative Prostate Cancer Risk SNP in an Androgen Receptor-Binding Site of the Melanophilin Gene Illustrates Enrichment of Risk SNPs in Androgen Receptor Target Sites.
Human mutation - 1 Jan 2016
Bu Huajie, Narisu Narisu, Schlick Bettina, Rainer Johannes, Manke Thomas, Schäfer Georg, Pasqualini Lorenza, Chines Peter, Schweiger Michal R, Fuchsberger Christian, Klocker Helmut
Abstract excerpt
Genome-wide association studies have identified genomic loci, whose single-nucleotide polymorphisms (SNPs) predispose to prostate cancer (PCa). However, the mechanisms of most of these variants are largely unknown. We integrated chromatin-immunoprecipitation-coupled sequencing and microarray expression profiling in TMPRSS2-ERG gene rearrangement positive DUCaP cells with the GWAS PCa risk SNPs catalog to identify...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.