Article
A biallelic multiple nucleotide length polymorphism explains functional causality at 5p15.33 prostate cancer risk locus.
Nature communications - 23 Aug 2023
Spisak Sandor, Tisza Viktoria, Nuzzo Pier Vitale, Seo Ji-Heui, Pataki Balint, Ribli Dezso, Sztupinszki Zsofia, Bell Connor, Rohanizadegan Mersedeh, Stillman David R, Alaiwi Sarah Abou, Bartels Alan H, Papp Marton, Shetty Anamay, Abbasi Forough, Lin Xianzhi, Lawrenson Kate, Gayther Simon A, Pomerantz Mark, Baca Sylvan, Solymosi Norbert, Csabai Istvan, Szallasi Zoltan, Gusev Alexander, Freedman Matthew L
Abstract excerpt
To date, single-nucleotide polymorphisms (SNPs) have been the most intensively investigated class of polymorphisms in genome wide associations studies (GWAS), however, other classes such as insertion-deletion or multiple nucleotide length polymorphism (MNLPs) may also confer disease risk. Multiple reports have shown that the 5p15.33 prostate cancer risk region is a particularly strong expression quantitative...
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