Article
Androgen regulation of the TMPRSS2 gene and the effect of a SNP in an androgen response element.
Molecular endocrinology (Baltimore, Md.) - 1 Dec 2013
Clinckemalie Liesbeth, Spans Lien, Dubois Vanessa, Laurent Michaël, Helsen Christine, Joniau Steven, Claessens Frank
Abstract excerpt
More than 50% of prostate cancers have undergone a genomic reorganization that juxtaposes the androgen-regulated promoter of TMPRSS2 and the protein coding parts of several ETS oncogenes. These gene fusions lead to prostate-specific and androgen-induced ETS expression and are associated with aggressive lesions, poor prognosis, and early-onset prostate cancer. In this study, we showed that an enhancer at 13 kb...
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