Article
A genome-wide survey over the ChIP-on-chip identified androgen receptor-binding genomic regions identifies a novel prostate cancer susceptibility locus at 12q13.13.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Nov 2011
Feng Junjie, Sun Jielin, Kim Seong-Tae, Lu Yizhen, Wang Zhong, Zhang Zheng, Gronberg Henrik, Isaacs William B, Zheng S Lilly, Xu Jianfeng
Abstract excerpt
BACKGROUND: The molecular mechanisms for the genome-wide association studies (GWAS)-identified prostate cancer (PCa) risk-associated single-nucleotide polymorphisms (SNP) remain largely unexplained. One recent finding that the PCa risk SNPs are enriched in genomic regions containing androgen receptor (AR)-binding sites has suggested altered AR signaling as a potentially important mechanism. METHODS: To explore...
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