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Article

A novel germline PALB2 deletion in Polish breast and ovarian cancer patients.

BMC medical genetics - 2 Feb 2010

Dansonka-Mieszkowska Agnieszka, Kluska Anna, Moes Joanna, Dabrowska Michalina, Nowakowska Dorota, Niwinska Anna, Derlatka Pawel, Cendrowski Krzysztof, Kupryjanczyk Jolanta

Abstract excerpt

BACKGROUND: PALB2 protein was recently identified as a partner of BRCA1 and BRCA2 which determines their proper function in DNA repair. METHODS: Initially, the entire coding sequence of the PALB2 gene with exon/intron boundaries was evaluated by the PCR-SSCP and direct sequencing methods on 70 ovarian carcinomas. Sequence variants of interest were further studied on enlarged groups of ovarian carcinomas (total...

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Source

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Identifiers

PMID: 20122277
DOI: 10.1186/1471-2350-11-20
PMCID: PMC2829009

Genes

PALB2
BRCA2
BRCA1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Clinical outcomes in women with breast cancer and a PALB2 mutation: a prospective cohort analysis.Semantic proximity Read ↗

Recurrent mutations of BRCA1, BRCA2 and PALB2 in the population of breast and ovarian cancer patients in Southern PolandSemantic proximity Read ↗

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