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Article

The Disintegrin and Metalloprotease ADAM12 Is Associated with TGF-β-Induced Epithelial to Mesenchymal Transition.

PloS one - 1 Jan 2015

Ruff Michaël, Leyme Anthony, Le Cann Fabienne, Bonnier Dominique, Le Seyec Jacques, Chesnel Franck, Fattet Laurent, Rimokh Ruth, Baffet Georges, Théret Nathalie

Abstract excerpt

The increased expression of the Disintegrin and Metalloprotease ADAM12 has been associated with human cancers, however its role remain unclear. We have previously reported that ADAM12 expression is induced by the transforming growth factor, TGF-β and promotes TGF-β-dependent signaling through interaction with the type II receptor of TGF-β. Here we explore the implication of ADAM12 in TGF-β-mediated epithelial to...

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Source

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Identifiers

PMID: 26407179
DOI: 10.1371/journal.pone.0139179
PMCID: PMC4583281

Genes

ADAM12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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