Back to search

Article

Deciphering the Role of ADAMTS6 in the Epithelial–Mesenchymal Transition of Lung Adenocarcinoma Cells

2025-12-03

Abstract excerpt

A disintegrin and metalloproteinase with thrombospondin motifs 6 (ADAMTS6) is an extracellular protease that promotes the invasion of lung adenocarcinoma (LUAD) cells. Herein, we investigate its role in epithelial-mesenchymal transition (EMT), a process that drives metastasis and drug resistance in LUAD. Re-analysis of microarray and RNA sequencing data from LUAD cells reveals that during EMT, TGF-β1 increases ADA...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
dad66efd-4889-5aa8-a828-fbd15017af39
DOI
10.20944/preprints202512.0265.v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Deciphering the Role of ADAMTS6 in the Epithelial–Mesenchymal Transition of Lung Adenocarcinoma CellsDOI 10.20944/preprints202512.0265.v1
Epithelial-mesenchymal transition markers screened in a cell-based model and validated in lung adenocarcinomaSemantic proximity
The Disintegrin and Metalloprotease ADAM12 Is Associated with TGF-β-Induced Epithelial to Mesenchymal Transition.Semantic proximity
RGS6 suppresses TGF-β-induced epithelial–mesenchymal transition in non-small cell lung cancers via a novel mechanism dependent on its interaction with SMAD4Semantic proximity
TGFβ1-Induced EMT in the MCF10A Mammary Epithelial Cell Line Model Is Executed Independently of SNAIL1 and ZEB1 but Relies on JUNB-Coordinated Transcriptional RegulationSemantic proximity
Bioinformatic approaches to augment study of epithelial-to-mesenchymal transition in lung cancerSemantic proximity
ADAM17 is overexpressed in non-small cell lung cancer and its expression correlates with poor patient survivalSemantic proximity
ADAM12 induction by Twist1 promotes tumor invasion and metastasis via regulation of invadopodia and focal adhesionsSemantic proximity
Shake It Up Baby Now: The Changing Focus on TWIST1 and Epithelial to Mesenchymal Transition in Cancer and Other DiseasesSemantic proximity
SMAD6 Contributes to Patient Survival in Non–Small Cell Lung Cancer and Its Knockdown Reestablishes TGF-β Homeostasis in Lung Cancer CellsSemantic proximity
ADAM12 as a Clinical Prognostic Indicator Associated with Tumour Immune Infiltration in Lung AdenocarcinomaSemantic proximity
The Correlation Between Immune Invasion and SARS-COV-2 Entry Protein ADAM17 in Cancer Patients by Bioinformatic AnalysisSemantic proximity
ADAM8 in invasive cancers: links to tumor progression, metastasis, and chemoresistanceSemantic proximity
Select a neighboring publication to make it the new centre.