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Article

Metalloprotease-disintegrin ADAM12 actively promotes the stem cell-like phenotype in claudin-low breast cancer.

Molecular cancer - 1 Feb 2017

Duhachek-Muggy Sara, Qi Yue, Wise Randi, Alyahya Linda, Li Hui, Hodge Jacob, Zolkiewska Anna

Abstract excerpt

BACKGROUND: ADAM12 is upregulated in human breast cancers and is a predictor of chemoresistance in estrogen receptor-negative tumors. ADAM12 is induced during epithelial-to-mesenchymal transition, a feature associated with claudin-low breast tumors, which are enriched in cancer stem cell (CSC) markers. It is currently unknown whether ADAM12 plays an active role in promoting the CSC phenotype in breast cancer...

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Identifiers

PMID: 28148288
DOI: 10.1186/s12943-017-0599-6
PMCID: PMC5288940

Genes

ADAM12
EGFR
EGF

Provenance

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