Secreted and membrane-bound isoforms of protease ADAM9 have opposing effects on breast cancer cell migration.

doi:10.1158/0008-5472.CAN-09-4231

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Article

Secreted and membrane-bound isoforms of protease ADAM9 have opposing effects on breast cancer cell migration.

Cancer research - 15 Oct 2010

Fry Jessica L, Toker Alex

Abstract excerpt

Tumor cell migration is mediated by cell-autonomous signaling mechanisms as well as paracrine and autocrine factors secreted by activated stromal cells in the tumor microenvironment. Like other members of the ADAM (a disintegrin and metalloproteinase) family, the integrin-binding metalloproteinase ADAM9 modulates cell-cell and cell-matrix interactions as well as ectodomain shedding of cell surface receptors and...

Topics

ADAM Proteins
Breast Neoplasms
Cell Line, Tumor
Cell Membrane
Cell Movement
Cross Reactions
DNA Primers
Disease Progression
Female
Gene Expression Regulation, Enzymologic
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunoblotting

Isoenzymes

Membrane Proteins

Mutation

RNA, Small Interfering

Sequence Deletion

Transfection

Source

Open in PubMed Open full text

Identifiers

PMID: 20736367
DOI: 10.1158/0008-5472.CAN-09-4231
PMCID: PMC2955804

Genes

ADAM9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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