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ADAM8 in invasive cancers: links to tumor progression, metastasis, and chemoresistance

1 Jan 2019

Abstract excerpt

Ectodomain shedding of extracellular and membrane proteins is of fundamental importance for cell-cell communication in neoplasias. A Disintegrin And Metalloproteinase (ADAM) proteases constitute a family of multifunctional, membrane-bound proteins with traditional sheddase functions. Their protumorigenic potential has been attributed to both, essential (ADAM10 and ADAM17) and 'dispensable' ADAM proteases (ADAM8,...

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PMID: 30635388
DOI: 10.1042/cs20180906

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