Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ADAM12 induction by Twist1 promotes tumor invasion and metastasis via regulation of invadopodia and focal adhesions

4 May 2017

Abstract excerpt

ABSTRACT The Twist1 transcription factor promotes tumor invasion and metastasis by inducing epithelial–mesenchymal transition (EMT) and invadopodia-mediated extracellular matrix (ECM) degradation. The critical transcription targets of Twist1 for mediating these events remain to be uncovered. Here, we report that Twist1 strongly induces expression of a disintegrin and metalloproteinase 12 (ADAM12). We observed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Adhesion Molecules Research
Share to Cellular Mechanics and Interactions
Share to HER2/EGFR in Cancer Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28468988
DOI: 10.1242/jcs.198200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ADAM12 induction by Twist1 promotes tumor invasion and metastasis via regulation of invadopodia and focal adhesionsPMID 28468988Read ↗

Deciphering the Role of ADAMTS6 in the Epithelial–Mesenchymal Transition of Lung Adenocarcinoma CellsSemantic proximity Read ↗

miR-720 is a downstream target of an ADAM8-induced ERK signaling cascade that promotes the migratory and invasive phenotype of triple-negative breast cancer cellsSemantic proximity Read ↗

ADAM8 expression in invasive breast cancer promotes tumor dissemination and metastasis.Semantic proximity Read ↗

Twist1 and AP-1 cooperatively upregulate integrin α5 expression to induce invasion and the epithelial–mesenchymal transitionSemantic proximity Read ↗

Twist1-Induced Epithelial Dissemination Requires Prkd1 SignalingSemantic proximity Read ↗

TWIST1 Is an ERK1/2 Effector That Promotes Invasion and Regulates MMP-1 Expression in Human Melanoma CellsSemantic proximity Read ↗

The Disintegrin and Metalloprotease ADAM12 Is Associated with TGF-β-Induced Epithelial to Mesenchymal Transition.Semantic proximity Read ↗

Over-Expressed Twist Associates with Markers of Epithelial Mesenchymal Transition and Predicts Poor Prognosis in Breast Cancers via ERK and Akt ActivationSemantic proximity Read ↗

TWIST1 associates with NF-κB subunit RELA via carboxyl-terminal WR domain to promote cell autonomous invasion through IL8 productionSemantic proximity Read ↗

A twist tale of cancer metastasis and tumor angiogenesis.Semantic proximity Read ↗

ADAM8 in invasive cancers: links to tumor progression, metastasis, and chemoresistanceSemantic proximity Read ↗

CADM1 is a TWIST1-regulated suppressor of invasion and survivalSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.